What is it?

Tramadol is a synthetic opioid that also affects serotonin and noradrenaline and acts like SNRI and SSRI antidepressants.
While tramadol and oxycodone are both depressants, they are very different substances.
Combining tramadol with drugs that affect serotonin can cause serotonin toxicity, a serious medical emergency. These include:
– MDMA
– Methamphetamine
– Cathinones like mephedrone
– Antidepressants (SSRIs, SNRIs, MAOIs, TCAs)

Combining tramadol with other depressants (e.g. alcohol, benzodiazepines) can cause respiratory depression and overdose.

Signs of serotonin toxicity include:
– Agitation or confusion
– Heavy sweating, feeling very hot
– Shaking, muscle twitching or stiff muscles
– Rapid heart rate or chest pain
– Loss of consciousness or seizures

What to do:
– Call triple zero ‘000’
– Keep the person cool
– Place in the recovery position
– Stay with the person until help arrives